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2 From 1965 to 2010, the prevalence of cigarette smoking in the United States has declined from 42.4% to about 19%

Market analyst reports estimate that Japan has the worlds biggest HTP market, with 85 percent of global sales in 2018

the second-highest number of publications was in the United Kingdom ( n = 196

REDUCED EXPOSURE CLAIM ONLY EFFECTIVE IF USERS COMPLETELY SWITCH FROM CIGARETTES Its also important to note that the reduced exposure claim permitted by the FDA applies to users who switch completely from conventional cigarettes to IQOS not to those who use IQOS and traditional cigarettes at the same time, which is likely to happen